Clinical and Hematological Effect of Acepromazine, Midazolam, Ketamine as General Anesthetic Protocol in Rabbits

This study was performing to evaluate the efficiency of Acepromazine, as tranquilizer and efficiency of using mixture of midazolam combination with ketamine as a general anesthetic protocols in rabbits. Ten adult local breed rabbits from both sexes were use in this study. Animals were anesthetized by intramuscularly injection of acepromazine 0.1 mg/kg B.W. five minutes later, animals were giving mixture of midazolam 1 mg / Kg B.W and ketamine 30mg/Kg B.W, in same syringe. Physiologic parameters evaluated in zero time as control and each 15 minutes interval until 90 minutes. It was including body temperature, respiratory rate, muscle relaxation, analgesia and stages of anesthesia (Induction of anesthesia, surgical anesthesia and recovery time). Hematological was study by giving 0.5 ml from marginal ear vein for Hg, PCV, WBCs, RBC, MCHC, MCV and MCH in zero time before any injection, 1 hr after anesthesia, 2 hr and 24 hrs. The results of this combination was provide good general anesthesia regimen with individual variation in anesthetic time with little effect on physiological parameters. Hematological results were showed marked decrease in (Red blood cells) RBC count 1 and 2 hours, and increased in (White blood cells) WBC count 1, 2, and 24 hours after administration of acepromazine ,midazolam ,ketamine, respectively .